Posts for: August, 2015

           Does chronic moderate to severe inflammation on the outside of the body (ie,the skin)

indicate significant inflammation on the inside of the body (ie,the internal organs ) ?

           Recent studies seem to be pointing in this direction (please see my  3 previous

posts on Psoriasis). In addition to these 3 articles another example of this skin-internal 

body correlation is that men with psoriasis seem to be more prone to the "wet" or more

serious (vs."dry" )  type of age-related macular degeneration of the eye.

          Another example involves  recent research indicating that moderate to severe

Acne Rosacea,the "adult" type of acne made worse by heat and sun-exposure vs. the

so-called teenage Acne Vulgarus-which,by the way,many  adults still have late in life,

is associated with coronary(heart) artery disease.

          And,the authors of the study  suggest that patients with Acne Rosacea be screened

for coronary vascular risk factors such as hypertension,diabetes,and  high cholesterol.

         In  fact,then, it is becoming more and more clear that any disorder with chronic

moderate to severe inflammation-whether external or internal- may be associated with

coronary artery disease risk and metabolic consequences.

         The bottom line again is  regular checkups with their healthcare provider and to report

any changes in body signs or symptoms at once.

Coming soon.


The following list of medications is certainly not all-inclusive since many different classes of

prescription and over-the-counter drugs can make the skin more sensitive to ultraviolet rays.

Some of the more popular photosensitizing medications include:

          Antibiotics: tetracycline,doxycycline hyclate(not the smaller-dose doxycycline found

in the brand name product "Oracea.") and sulfa-containing antibiotics such as trimethoprim/

sulfamethoxazole.

         Arthritis drugs: ibuprofen, naproxen

        Blood pressure/"water pill" drugs: hydrochlorthiazide(more a blood pressure drug than

a water pill) furosemide(more a water pill than a blood pressure drug).Both of these contain

sulfa,which is a photosensitizer.

       A recent study indicated that the calcium channel blocker nifedipine and the ACE

inhibitor lisinopril both increased sun-sensitivity and made users more likely to develop

lip cancer.

       Diabetes drugs: glipizide,glyburide, and chlorpropamide all contain sulfa and,therefore,

are more likely to be sun-sensitizers.

      Antihistamine:  the popular diphenhydramine

     Acne medications: include those related to Vitamin A such as  isotretinoin,tretinoin,and

acetretin.

    Anti-cancer(chemotherapy) drugs:  5-fluorouracil  and dacarbazine

    Psychiatric drugs such as the major tranquilizers chlorpromazine and the tricyclic 

antidepressants  desipramine and imipramine.

   External (topical) products such as scented or deordorant soaps, toiletries, cosmetics or fragrances

         In summary,  the benefit of these drugs probably outweighs the potential sun-senitivity side

effects (especially with the judicious use of sunscreens and sun exposure time). If not,they

should only be discontinued with the consent of the health care practitioner prescribing

them.

 

 

 




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