The risk of antibiotic resistance in treating Acne and the "killing off"  of

the so-called  "good germs" in our body's gastrointestinal and respiratory

tracts-which in itself can lead to illness-has lead to the recommendation

that internal antibiotic use be limited to a few months.

          In fact, one of the main take aways from a 2015 study was that a

subantimicrobial release version of a popular acne drug called doxycycline 40 mgs

given once daily to patients 12 years of age or older with moderate to severe

inflammatory acne for 16 weeks had comparable efficacy to doxycycline 100mgs

daily for the same 16 week time period  with superior safety via markedly less

drug-related adverse events.