A drug with the generic name tofacitnib citrate , which is in a class of drugs called
Janus kinase inhibitors which prevent the production of cytokines which mediate
inflammation, is being used for a severe type of eczema called atopic dermatitis.
Atopic dermatitis is a type of skin inflammation characterized by itching,red and
cracked skin with a preponderance for the back of the knees and front of the elbows.
It has a definite genetic predisposition and many people with it are more prone to asthma
and hayfever.
Janus kinase inhibitors (JAK) are also being proposed for psoriasis, vitiligo (loss of skin
pigment), and the type of hair loss called alopecia areata.
In addition, Janus kinase inhibitor drugs are used for rheumatoid arthritis.
Although generally well tolerated, Janus kinase inhibitors can lead to opportunistic infections,
malignancies, and elevated lipids (cholesterol, triglycerides). I
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