A drug with the generic name tofacitnib citrate , which is in a class of drugs called

 Janus kinase inhibitors  which prevent the production of cytokines which mediate

 inflammation, is being used for a severe type of eczema called atopic dermatitis.

 Atopic dermatitis is a type of skin inflammation characterized by itching,red and

cracked skin with a preponderance for the back of the knees and front of the elbows.

 It has a definite genetic predisposition and many people with it are more prone to asthma

 and hayfever.

 Janus kinase inhibitors (JAK) are also being proposed for psoriasis, vitiligo (loss of skin

 pigment), and the type of hair loss called alopecia areata.

 In addition, Janus kinase  inhibitor drugs are used for rheumatoid arthritis.

 Although generally well tolerated, Janus kinase inhibitors can lead to opportunistic infections,

 malignancies, and elevated lipids (cholesterol, triglycerides). I