Posts for tag: ibuprofen

             A new type of therapy called immunotherapy Is increasingly being used  to 

fight cancer.In essence,this therapy utilizes the body's own cancer-killing cells

as a defense mechanism against the cancer cells.To begin with, cancerous

tissue is biopsied and tested for genetic mutations. Then, medications called

monoclonal antibodies which are specific for each of these genetic mutations

in a given cancer are then used to enlist the body's own cancer-fighting cells

to destroy the cancer.

              Recently,a former president who suffered from malignant melanoma

which had already spread to his liver and brain was given the drug pembrolizumab.

This medication is one of a new class of drugs called immune checkpoint inhibitors.

These drugs target certain proteins in the immune system known as checkpoint 

proteins which prevent cancer cells from being attacked by the  immune system.

Therefore,they allow the body's own immune system to attack and kill the cancer.

             In a recent study of 67 patients utilizing this therapy,about 17 (ie,25 %)

developed a skin condition  on certain body areas known as vitiligo which is

the absence of pigment. 

             However,not only is this, in my opinion,a very small price to pay for

curing melanoma cancer which has already spread throughout the body,

but this potential side effect and others can be managed by the use of

steroids and aspirin type drugs such as ibuprofen and naproxen.






Coming soon.

The following list of medications is certainly not all-inclusive since many different classes of

prescription and over-the-counter drugs can make the skin more sensitive to ultraviolet rays.

Some of the more popular photosensitizing medications include:

          Antibiotics: tetracycline,doxycycline hyclate(not the smaller-dose doxycycline found

in the brand name product "Oracea.") and sulfa-containing antibiotics such as trimethoprim/


         Arthritis drugs: ibuprofen, naproxen

        Blood pressure/"water pill" drugs: hydrochlorthiazide(more a blood pressure drug than

a water pill) furosemide(more a water pill than a blood pressure drug).Both of these contain

sulfa,which is a photosensitizer.

       A recent study indicated that the calcium channel blocker nifedipine and the ACE

inhibitor lisinopril both increased sun-sensitivity and made users more likely to develop

lip cancer.

       Diabetes drugs: glipizide,glyburide, and chlorpropamide all contain sulfa and,therefore,

are more likely to be sun-sensitizers.

      Antihistamine:  the popular diphenhydramine

     Acne medications: include those related to Vitamin A such as  isotretinoin,tretinoin,and


    Anti-cancer(chemotherapy) drugs:  5-fluorouracil  and dacarbazine

    Psychiatric drugs such as the major tranquilizers chlorpromazine and the tricyclic 

antidepressants  desipramine and imipramine.

   External (topical) products such as scented or deordorant soaps, toiletries, cosmetics or fragrances

         In summary,  the benefit of these drugs probably outweighs the potential sun-senitivity side

effects (especially with the judicious use of sunscreens and sun exposure time). If not,they

should only be discontinued with the consent of the health care practitioner prescribing