A few years ago one of my male patients presented with a groin rash of several months duration
which was unresponsive to various topical antifungals and topical corticosteroids prescribed by his health care
practitioner.
The rash was red and scaly encompassing his groin and extending to his scrotal area.There was
associated itching and burning at times. The most important clue here was that the rash had been chronically
unresponsive to the above measures.
Consequently,I suspected a condition called extra mammary Paget's disease (EMPD) which
fortunately is a rare cancerous condition of apocrine gland-bearing sites.
In addition,two types of EMPD have been described:the primary type thought to arise from a stem
cell within genital skin and not associated with an underlying internal malignancy involving the rectum
and/or other internal body areas.However,the primary type is still a carcinoma of the skin and needs to
be treated.
Secondary EMPD is the more dangerous type since it is associated with an underlying adnexal
(connected) adenocarcinoma or an underlying visceral(internal) cancer and is the same as mammary
Paget's disease of the breast(nipple).
Fortunately,I referred my patient to a general surgeon for a deep excisional biopsy which confirmed
my clinical diagnosis.The presence of a cellular protein called cytokeratin 20 helps to differentiate
between the primary and secondary types on biopsy.
In addition,the presence of a gene called HER-2 in the biopsy specimen may indicate a high risk
for lymphatic spread and the need to follow the patient very diligently.
EMPD most frequently involves the vulva in women,the perianal area,perineum,scrotum,penis and
axillae(armpits). Treatment includes wide surgical excision,radiation therapy,and several topical(external)
agents.
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